Aprotinin impairs coronary endothelial function and down-regulates endothelial NOS in rat coronary microvascular endothelial cells
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چکیده
منابع مشابه
Aprotinin impairs coronary endothelial function and down-regulates endothelial NOS in rat coronary microvascular endothelial cells.
OBJECTIVE The non-specific serine protease inhibitor aprotinin is currently used to reduce blood loss and the need for blood transfusion after cardiopulmonary bypass. We have recently reported that aprotinin impairs endothelium-dependent but not endothelium-independent relaxations in rat thoracic aortic rings due to its inhibitory effect on endothelial nitric oxide (NO) production. In light of ...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2002
ISSN: 0008-6363
DOI: 10.1016/s0008-6363(02)00489-3